Conformational and lipid bilayer-perturbing properties of Marburg virus GP2 segments containing the fusion loop and membrane-proximal external region/transmembrane domain
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e03018
Abstract: Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined “class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the… read more here.
Keywords: marburg virus; gp2; membrane proximal; fusion ... See more keywords
Spike protein fusion loop controls SARS-CoV-2 fusogenicity and infectivity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Structural Biology"
DOI: 10.1016/j.jsb.2021.107713
Abstract: The high SARS-CoV-2 reproductive number driving the COVID-19 pandemic has been a mystery. Our recent in vitro, and in vivo coronaviral pathogenesis studies involving Mouse Hepatitis Virus (MHV-A59) suggest a crucial role for a small… read more here.
Keywords: fusion; sars cov; fusogenicity; virus ... See more keywords
Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essential for Viral Infectivity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00064-22
Abstract: Alphaviruses are human pathogens that cause both debilitating acute and chronic musculoskeletal disease and potentially fatal encephalitis. In this study, we determined that two highly conserved phenylalanine residues in the alphavirus E1 glycoprotein are required… read more here.
Keywords: fusion loop; phenylalanine residues; fusion; f87a f95a ... See more keywords