Molecular Underpinnings Governing Genetic Complexity of ETS-Fusion-Negative Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2019.07.001
Abstract: Inter- and intra-patient molecular heterogeneity of primary and metastatic prostate cancer (PCa) confers variable clinical outcome and poses a formidable challenge in disease management. High-throughput integrative genomics and functional approaches have untangled the complexity involved… read more here.
Keywords: ets fusion; molecular underpinnings; fusion negative; prostate cancer ... See more keywords
Fusion-negative rhabdomyosarcoma with diffuse bony metastases and remarkable chemosensitivity
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-250236
Abstract: In this report, we describe the case of an adolescent male with an unusual case of fusion-negative, paratesticular alveolar rhabdomyosarcoma who presented with spontaneous tumour lysis syndrome and diffuse bony metastases throughout the axial and… read more here.
Keywords: bony metastases; rhabdomyosarcoma; diffuse bony; fusion negative ... See more keywords
Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1061570
Abstract: Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma that includes fusion-positive (FP) and fusion-negative (FN) molecular subtypes. FP-RMS expresses PAX3-FOXO1 fusion protein and often shows dismal prognosis. FN-RMS shows cytogenetic abnormalities and frequently harbors… read more here.
Keywords: fusion; spermine; dna damage; fusion negative ... See more keywords
Genetic Characterization, Current Model Systems and Prognostic Stratification in PAX Fusion-Negative vs. PAX Fusion-Positive Rhabdomyosarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12101500
Abstract: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents and accounts for approximately 2% of soft tissue sarcomas in adults. It is subcategorized into distinct subtypes based on histological features and… read more here.
Keywords: stratification; model systems; fusion negative; pax fusion ... See more keywords