Fusion oncogenes—genetic musical chairs
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aau8231
Abstract: Ewing sarcoma–driver fusion genes can result from complex genomic rearrangements The cytogenetic definitions of many cancers predate the genome sequencing era. Indeed, some classes of cancers (largely subtypes of sarcomas, lymphomas, and leukemias) have long… read more here.
Keywords: genetic musical; musical chairs; oncogenes genetic; translocation ... See more keywords
Clinically relevant fusion oncogenes: detection and practical implications
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/17588359221144108
Abstract: Mechanistically, chimeric genes result from DNA rearrangements and include parts of preexisting normal genes combined at the genomic junction site. Some rearranged genes encode pathological proteins with altered molecular functions. Those which can aberrantly promote… read more here.
Keywords: fusion; fusion oncogenes; rtk fusion; relevant fusion ... See more keywords