New Engineered Fusion Peptide with Dual Functionality: Antibacterial and Strong Binding to Hydroxyapatite
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09963-8
Abstract: One of the main challenges in oral disease is prevention of bacterial infections considering antibiotic resistance as a result of frequent use of conventional antibiotics. A natural alternative to these chemical antibiotics is antimicrobial peptide… read more here.
Keywords: new engineered; fusion peptide; habp ll37; peptide ... See more keywords
A TCR-like antibody against a proinsulin-containing fusion peptide ameliorates type 1 diabetes in NOD mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.019
Abstract: Type 1 diabetes (T1D) is an autoimmune disease caused by destruction of insulin-producing β cells. The response of autoreactive T cells to β cell antigens plays a central role in the development of T1D. Recently,… read more here.
Keywords: tcr like; fusion peptide; type diabetes; fusion ... See more keywords
Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107981
Abstract: The HIV fusion peptide (FP) is a promising vaccine target. FP-directed monoclonal antibodies from vaccinated macaques have been identified that neutralize up to ∼60% of HIV strains; these vaccinations, however, have involved ∼1 year with… read more here.
Keywords: immune monitoring; fusion peptide; imprint cross; neutralizing responses ... See more keywords
An approach for half‐life extension and activity preservation of an anti‐diabetic peptide drug based on genetic fusion with an albumin‐binding aptide
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.04.036
Abstract: Abstract Although the peptide, exenatide, has been widely used as a drug for the treatment of type 2 diabetes, its short plasma half‐life requires frequent subcutaneous injection, resulting in poor patient compliance in addition to… read more here.
Keywords: fusion; fusion peptide; exenatide apthsa; half life ... See more keywords
Enhanced Cholesterol-Dependent Hemifusion by Internal Fusion Peptide 1 of SARS Coronavirus-2 Compared to Its N-Terminal Counterpart
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00046
Abstract: Membrane fusion is an important step for the entry of the lipid-sheathed viruses into the host cells. The fusion process is being carried out by fusion proteins present in the viral envelope. The class I… read more here.
Keywords: hemifusion; fusion peptide; fusion; terminal counterpart ... See more keywords
Parainfluenza Fusion Peptide Promotes Membrane Fusion by Assembling into Oligomeric Porelike Structures
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00208
Abstract: Paramyxoviruses are enveloped viruses harboring a negative-sense RNA genome that must enter the host’s cells to replicate. In the case of the parainfluenza virus, the cell entry process starts with the recognition and attachment to… read more here.
Keywords: fusion; membrane fusion; fusion peptide; pifp ... See more keywords
Effect of Cholesterol on Biomimetic Membrane Curvature and Coronavirus Fusion Peptide Encapsulation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c01095
Abstract: Biomimetic cubic phases can be used for protein encapsulation in a variety of applications such as biosensors and drug delivery. Cubic phases with a high concentration of cholesterol and phospholipids were obtained herein. It is… read more here.
Keywords: fusion; fusion peptide; biomimetic membrane; curvature ... See more keywords
Effect of Disulfide Bridge on the Binding of SARS-CoV-2 Fusion Peptide to Cell Membrane: A Coarse-Grained Study
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05079
Abstract: In this paper, we present the parameterization of the CAVS coarse-grained (CG) force field for 20 amino acids, and our CG simulations show that the CAVS force field could accurately predict the amino acid tendency… read more here.
Keywords: fusion peptide; binding sars; membrane; coarse grained ... See more keywords
Fusion Peptide of SARS-CoV-2 Spike Rearranges into a Wedge Inserted in Bilayered Micelles
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c05435
Abstract: The receptor binding and proteolysis of Spike of SARS-CoV-2 release its S2 subunit to rearrange and catalyze viral-cell fusion. This deploys the fusion peptide for insertion into the cell membranes targeted. We show that this… read more here.
Keywords: fusion peptide; inserted bilayered; bilayered micelles; peptide sars ... See more keywords
Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59711-y
Abstract: The vaccine elicitation of broadly neutralizing antibodies against HIV-1 is a long-sought goal. We previously reported the amino-terminal eight residues of the HIV-1-fusion peptide (FP8) – when conjugated to the carrier protein, keyhole limpet hemocyanin… read more here.
Keywords: vaccine immunogen; preclinical development; fusion peptide; carrier ... See more keywords
Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.01604-22
Abstract: The HIV-1 fusion peptide has been identified as a site for elicitation of broadly neutralizing antibodies, with prior studies demonstrating that priming with fusion peptide-based immunogens and boosting with soluble envelope (Env) trimers can elicit… read more here.
Keywords: hiv; fusion; peptide length; fusion peptide ... See more keywords