Phases of the exocytotic fusion pore
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13234
Abstract: Membrane fusion and fission are fundamental processes in living organisms. Membrane fusion occurs through the formation of a fusion pore, which is the structure that connects two lipid membranes during their fusion. Fusion pores can… read more here.
Keywords: fusion; phases exocytotic; fusion pore; exocytotic fusion ... See more keywords
Fusion Pore Selectivity in Chromaffin Cells
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2148
Abstract: Healthy physiological conditions depend on dynamic release of neurotransmitters and hormones by exocytosis, which is initiated by the fusion pore. Previous studies show that reduction of extracellular [NaCl] decreases the amperometric foot current, indicating no… read more here.
Keywords: chromaffin cells; foot current; fusion; fusion pore ... See more keywords
Effects of Membrane Tension on Snare-Mediated Single Fusion Pores
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2153
Abstract: Fast and temporally controlled release is imperative for neurotransmitter release via evoked synaptic vesicle exocytosis. This process is driven by the interaction between vesicle v-SNAREs with target t-SNAREs on the plasma membrane. The initial, nanometer-sized… read more here.
Keywords: membrane tension; snare mediated; fusion; fusion pores ... See more keywords
Asymmetric Phosphatidylethanolamine Distribution Controls Fusion Pore Lifetime and Probability.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.09.014
Abstract: Little attention has been given to how the asymmetric lipid distribution of the plasma membrane might facilitate fusion pore formation during exocytosis. Phosphatidylethanolamine (PE), a cone-shaped phospholipid, is predominantly located in the inner leaflet of… read more here.
Keywords: fusion; pore lifetime; fusion pore; plasma membrane ... See more keywords
Fusion Pore Formation Observed during SNARE-Mediated Vesicle Fusion with Pore-Spanning Membranes.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.05.023
Abstract: Planar pore-spanning membranes (PSMs) have been shown to be a versatile tool to resolve elementary steps of the neuronal fusion process. However, in previous studies, we monitored only lipid mixing between fusing large unilamellar vesicles… read more here.
Keywords: pore spanning; fusion; fusion pore; pore formation ... See more keywords
SNARE-mediated vesicle navigation, vesicle anatomy and exocytotic fusion pore.
Sign Up to like & getrecommendations! Published in 2018 at "Cell calcium"
DOI: 10.1016/j.ceca.2018.03.004
Abstract: The focus of this special issue (SI) »Membrane Merger in Conventional and Unconventional Vesicle Secretion« is regulated exocytosis, a universally conserved mechanism, consisting of a merger between the vesicle and the plasma membranes. Although this… read more here.
Keywords: fusion pore; exocytotic fusion; anatomy; vesicle ... See more keywords
The Synaptotagmin-1 C2B Domain Is a Key Regulator in the Stabilization of the Fusion Pore.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.0c00734
Abstract: Fusion pores serve as an effective mechanism to connect intracellular organelles and release vesicle contents during exocytosis. A complex lipid rearrangement takes place as membranes approximate, bend, fuse, and establish a traversing water channel to… read more here.
Keywords: fusion; fusion pore; synaptotagmin c2b; c2b domain ... See more keywords
Enhanced Expansion and Reduced Kiss-and-Run Events in Fusion Pores Steered by Synaptotagmin-1 C2B Domains.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.2c00424
Abstract: The fusion pore controls the release of exocytotic vesicle contents through a precise orchestration of lipids from the fusing membranes and proteins. There is a major lipid reorganization during the different stages in life of… read more here.
Keywords: fusion; synaptotagmin c2b; fusion pore; c2b domains ... See more keywords
Novel Roles of the Nipah Virus Attachment Glycoprotein and Its Mobility in Early and Late Membrane Fusion Steps
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03222-21
Abstract: The important Paramyxoviridae family includes measles, mumps, human parainfluenza, and the emerging deadly zoonotic Nipah virus (NiV) and Hendra virus (HeV). The deadly emerging NiV can cause neurologic and respiratory symptoms in humans with a >60%… read more here.
Keywords: fusion; membrane fusion; nipah virus; fusion pore ... See more keywords
The F-Actin Binding Protein Cortactin Regulates the Dynamics of the Exocytotic Fusion Pore through its SH3 Domain
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00130
Abstract: Upon cell stimulation, the network of cortical actin filaments is rearranged to facilitate the neurosecretory process. This actin rearrangement includes both disruption of the preexisting actin network and de novo actin polymerization. However, the mechanism… read more here.
Keywords: actin; cortactin; fusion pore; actin polymerization ... See more keywords