Combined detection of the ActRII-Fc fusion proteins Sotatercept (ActRIIA-Fc) and Luspatercept (modified ActRIIB-Fc) in serum by means of immunoaffinity purification, tryptic digestion, and LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2018 at "Drug testing and analysis"
DOI: 10.1002/dta.2513
Abstract: Therapeutic proteins are a continuously growing class of pharmaceuticals and comprise several drug candidates with potential performance-enhancing properties. In particular, activin receptor competitors, such as the ActRII-Fc fusion proteins Sotatercept (ActRIIA-Fc) and Luspatercept (modified ActRIIB-Fc),… read more here.
Keywords: detection; fusion proteins; sotatercept actriia; proteins sotatercept ... See more keywords
HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma
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DOI: 10.1002/hep.30127
Abstract: About 15% of intrahepatic cholangiocarcinomas (ICCs) express constitutively active fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs) generated by chromosomal translocations. FFs have been nominated as oncogenic drivers because administration of FGFR tyrosine kinase… read more here.
Keywords: hsp90; fusion proteins; fgfr2 fusion; bgj398 ... See more keywords
The oncogenic fusion landscape in pediatric CNS neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "Acta Neuropathologica"
DOI: 10.1007/s00401-022-02405-8
Abstract: Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-related deaths in children. Recent developments in molecular analyses have greatly contributed to a more accurate diagnosis and risk stratification of CNS… read more here.
Keywords: fusion; cns; pediatric cns; cns neoplasms ... See more keywords
Brian A. Baldo, Safety of Biologics Therapy: Monoclonal Antibodies, Cytokines, Fusion Proteins, Hormones, Enzymes, Coagulation Proteins, Vaccines, Botulinum Toxins, 1st Edition, Springer, 2016, Print Book ISBN: 978-3-319-30470-0, e-Book ISBN 978-3-319-30472-4
Sign Up to like & getrecommendations! Published in 2017 at "Drug Safety"
DOI: 10.1007/s40264-017-0562-x
Abstract: This book has a very ambitious goal of providing an up-todate review of a wide range of biologics used as therapeutic agents and it is clearly stated that there are many new biologics being developed… read more here.
Keywords: fusion proteins; chapter; book isbn; book ... See more keywords
Mitochondrial Fusion Proteins: A Tale of Two Membranes
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DOI: 10.1016/j.bpj.2016.11.467
Abstract: Dynamins are a class of GTPase enzymes responsible for the fusion, fission, and vesiculation of cellular lipid membranes throughout the cell. The dynamin-like proteins Optic Atrophy 1 (Opa1) and Mitofusin (Mfn) 1 and 2 are… read more here.
Keywords: proteins tale; fusion proteins; tale two; mitochondrial fusion ... See more keywords
Isotype-specific outcomes in Fc gamma receptor targeting of PspA using fusion proteins as a vaccination strategy against Streptococcus pneumoniae infection.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.06.067
Abstract: Streptococcus pneumoniae (Spn) remains a considerable threat to public health despite the availability of antibiotics and polysaccharide conjugate vaccines. The lack of mucosal immunity in addition to capsular polysaccharide diversity, has proved to be problematic… read more here.
Keywords: strategy; fusion proteins; targeting pspa; streptococcus pneumoniae ... See more keywords
Exploration of Recombinant Fusion Proteins YAPO and YAPL as Carrier Proteins for Glycoconjugate Vaccine Design against Streptococcus pneumoniae Infection.
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DOI: 10.1021/acsinfecdis.0c00260
Abstract: Pneumolysin (Ply), pneumococcal surface protein A (PspA), and pneumococcal surface adhesin A (PsaA) are promising cell surface protein antigen targets for Streptococcus pneumoniae (Spn) vaccine development. Herein, we designed and recombined two fusion proteins, named… read more here.
Keywords: streptococcus pneumoniae; yapo yapl; fusion proteins; carrier proteins ... See more keywords
PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
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DOI: 10.1038/s42003-021-02801-y
Abstract: Pomalidomide and lenalidomide are immunomodulatory agents that were derived from thalidomide. Cereblon (CRBN) is a common direct target of thalidomide and related compounds and works as a Cullin Ring 4 E3 ubiquitin ligase (CRL4) with… read more here.
Keywords: crbn; fusion proteins; proteins pomalidomide; pomalidomide dependent ... See more keywords
Abstract 5770: Engineering and characterization of anti-PSMA humabody-deBouganin fusion proteins
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DOI: 10.1158/1538-7445.am2018-5770
Abstract: Targeted protein therapeutics or TPTs are single-protein therapeutics composed of targeting moieties genetically fused via peptide linker to cytotoxic protein payloads. TPTs are designed to overcome efficacy and safety challenges inherent within ADCs. For tumor… read more here.
Keywords: protein; fusion proteins; debouganin fusion; humabody ... See more keywords
ZFTA-translocations constitute ependymoma chromatin remodeling and transcription factors.
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DOI: 10.1158/2159-8290.cd-20-1052
Abstract: ZFTA (C11orf95)-a gene of unknown function-partners with a variety of transcriptional co-activators in translocations that drive supratentorial ependymoma, a frequently lethal brain tumor. Understanding the function of ZFTA is key to developing therapies that inhibit… read more here.
Keywords: chromatin; zfta; translocations constitute; fusion proteins ... See more keywords
Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Innate Immunity"
DOI: 10.1159/000492974
Abstract: Innate recognition of viruses is an essential part of the immune response to viral pathogens. This is integral to the maintenance of healthy lungs, which are free from infection and efficient at gaseous exchange. An… read more here.
Keywords: fusion proteins; immunity; surfactant proteins; viral fusion ... See more keywords