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Published in 2017 at "Cancer"
DOI: 10.1002/cncr.30510
Abstract: Novel fusion transcripts (FTs) caused by chromosomal rearrangement are common factors in the development of cancers. In the current study, the authors used massively parallel RNA sequencing to identify new FTs in colon cancers.
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Keywords:
fusion transcript;
klhl29ft generated;
nr5a2 klhl29ft;
novel fusion ... See more keywords
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Published in 2021 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2021.103303
Abstract: Chimeric transcripts are critical for diagnosis or prognosis and could constitute effective therapeutic targets. Fresh tissues are the major source for the identification of these fusion transcripts. The quality and quantity of the extracted RNA…
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Keywords:
fusion transcript;
transcript discovery;
ffpe tissues;
formalin fixed ... See more keywords
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Published in 2018 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2018.11.021
Abstract: Expression of the fusion genes is considered to be an important mechanism of tumorigenesis. However it is hardly ever discussed in relation to the neurodevelopmental disorders. Here we report on an 18-years-old female patient with…
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Keywords:
fusion transcript;
puf60 scrib;
scrib fusion;
verheij syndrome ... See more keywords
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Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx315
Abstract: Abstract The RNA-Seq technology has revolutionized transcriptome characterization not only by accurately quantifying gene expression, but also by the identification of novel transcripts like chimeric fusion transcripts. The ‘fusion’ or ‘chimeric’ transcripts have improved the…
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Keywords:
fusion;
rna seq;
fusion transcript;
chimerscope ... See more keywords
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Published in 2023 at "Neuro-Oncology Practice"
DOI: 10.1093/nop/npad022
Abstract: Recurrent gliomas are therapeutically challenging diseases with few treatment options available. One area of potential therapeutic vulnerability is the presence of targetable oncogenic fusion proteins. To better understand the clinical benefit of routinely testing for…
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Keywords:
fusion;
transcript panel;
adult glioma;
glioma patients ... See more keywords
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2
Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17481
Abstract: Read‐through fusion transcripts have recently been identified as chimeric RNAs and have since been linked to tumour growth in some cases. Many fusion genes generated by chromosomal rearrangements have been described in glioblastoma. However, read‐through…
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Keywords:
bcl2l2 pabpn1;
fusion;
fusion transcript;
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Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.10540
Abstract: 10540Background: NTRK (Neurotrophic receptor tyrosine kinase) fusion transcript was initially described in infantile fibrosarcoma (IFS) and is now known to be present in many other rare types of tu...
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Keywords:
fusion transcript;
study preliminary;
tag trak;
trak study ... See more keywords
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Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12123001
Abstract: NUP98::NSD1 fusion, a cryptic translocation of t(5;11)(q35;p15.5), occurs predominantly in pediatric AML, having a poor prognostic outcome. There are limited studies on the diagnosis of NUP98::NSD1 fusion in a clinical setting, and most of the…
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Keywords:
fusion;
aml patients;
nsd1 fusion;
nup98 nsd1 ... See more keywords