PVT1: a long non-coding RNA recurrently involved in neoplasia-associated fusion transcripts.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145497
Abstract: NGS technologies and bioinformatics tools allow the rapid identification of chimeric transcripts in cancer. More than 40,000 fusions are so far reported in the literature; however, for most of them, the role in oncogenesis is… read more here.
Keywords: non coding; coding rna; long non; fusion transcripts ... See more keywords
Lncrnas As New Partners of Novel Chimeric Transcripts in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-122568
Abstract: Deregulation of long non-coding RNAs (lncRNAs) is a common feature of cancer, including Multiple Myeloma (MM). In our previous studies, we detected 11,495 and 40,511 previously non-annotated lncRNAs during normal humoral immune response and MM… read more here.
Keywords: fusion; fusion transcripts; multiple myeloma; chimeric transcripts ... See more keywords
Whole transcriptome sequencing detects a large number of novel fusion transcripts in patients with AML and MDS.
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2020003007
Abstract: Fusion transcripts are frequent genetic abnormalities in myeloid malignancies and are often the basis for risk stratification, minimal residual disease (MRD) monitoring, and targeted therapy. We comprehensively analyzed the fusion transcript landscape in 572 acute… read more here.
Keywords: aml mds; fusion transcripts; novel fusions; whole transcriptome ... See more keywords
Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic Pathology"
DOI: 10.1186/s13000-019-0800-x
Abstract: A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these… read more here.
Keywords: fusion transcripts; ss18 ssx1; patients synovial; synovial sarcoma ... See more keywords
Novel transcription-induced fusion RNAs in prostate cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17099
Abstract: Prostate cancer is a clinically and pathologically heterogeneous disease with a broad spectrum of molecular abnormalities in the genome and transcriptome. One key feature is the involvement of chromosomal rearrangements creating fusion genes. Recent RNA-sequencing… read more here.
Keywords: cancer; transcription; fusion transcripts; prostate cancer ... See more keywords
A Deep Learning Approach to the Screening of Oncogenic Gene Fusions in Humans
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20071645
Abstract: Gene fusions have a very important role in the study of cancer development. In this regard, predicting the probability of protein fusion transcripts of developing into a cancer is a very challenging and yet not… read more here.
Keywords: gene fusions; fusion transcripts; learning approach; deep learning ... See more keywords
Assessment of BCR-ABL1 fusion transcripts and their association with response to imatinib treatment in chronic myeloid leukemia patients
Sign Up to like & getrecommendations! Published in 2018 at "Indian Journal of Medical and Paediatric Oncology"
DOI: 10.4103/ijmpo.ijmpo_80_17
Abstract: Objectives: BCR-ABL1 fusion transcripts with contrasting data on response to imatinib therapy have been reported from different parts of the world. Hence, the present study aimed to determine the frequencies of transcripts and their association… read more here.
Keywords: b3a2; fusion transcripts; response; imatinib ... See more keywords