Spike protein fusion loop controls SARS-CoV-2 fusogenicity and infectivity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Structural Biology"
DOI: 10.1016/j.jsb.2021.107713
Abstract: The high SARS-CoV-2 reproductive number driving the COVID-19 pandemic has been a mystery. Our recent in vitro, and in vivo coronaviral pathogenesis studies involving Mouse Hepatitis Virus (MHV-A59) suggest a crucial role for a small… read more here.
Keywords: fusion; sars cov; fusogenicity; virus ... See more keywords
SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00941-z
Abstract: Dear Editor, The SARS-CoV-2 Omicron variant has rapidly displaced the Delta variant and spread across the world. The Omicron variant harbors over 60 mutations, and 15 of the mutations are located in the receptor-binding domain… read more here.
Keywords: fusogenicity; sars cov; variant; omicron variant ... See more keywords
SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity
Sign Up to like & getrecommendations! Published in 2022 at "Cell Reports"
DOI: 10.1101/2022.05.07.491004
Abstract: Over 20 mutations have been identified in the N-Terminal Domain (NTD) of SARS-CoV-2 spike and yet few of them are fully characterised. Here we first examined the contribution of the NTD to infection and cell-cell… read more here.
Keywords: fusogenicity; cell; spike; entry ... See more keywords
Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf3731
Abstract: Measles virus (MeV), which is usually non-neurotropic, sometimes persists in the brain and causes subacute sclerosing panencephalitis (SSPE) several years after acute infection, serving as a model for persistent viral infections. The persisting MeVs have… read more here.
Keywords: fusogenicity; fusion; collective fusion; bloc transmitted ... See more keywords
Mapping Fusogenicity of Ciprofloxacin-Loaded Liposomes with Bacterial Cells
Sign Up to like & getrecommendations! Published in 2019 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-019-1381-4
Abstract: The process of liposome fusion with cellular membrane plays key role in delivering encapsulated drug molecule into the cell. This process becomes very important for molecules having low permeability as they fail to reach the… read more here.
Keywords: bacterial cells; loaded liposomes; cip loaded; fusogenicity ... See more keywords
Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011123
Abstract: SARS-CoV Spike (S) protein shares considerable homology with SARS-CoV-2 S, especially in the conserved S2 subunit (S2). S protein mediates coronavirus receptor binding and membrane fusion, and the latter activity can greatly influence coronavirus infection.… read more here.
Keywords: fusogenicity; substitution; spike; t813s ... See more keywords
Two Consecutive Prolines in the Fusion Peptide of Murine β-Coronavirus Spike Protein Predominantly Determine Fusogenicity and May Be Essential but Not Sufficient to Cause Demyelination
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040834
Abstract: Combined in silico, in vitro, and in vivo comparative studies between isogenic-recombinant Mouse-Hepatitis-Virus-RSA59 and its proline deletion mutant, revealed a remarkable contribution of centrally located two consecutive prolines (PP) from Spike protein fusion peptide (FP)… read more here.
Keywords: fusogenicity; rsmhv2; two consecutive; spike protein ... See more keywords
A Virus Genetic System to Analyze the Fusogenicity of Human Cytomegalovirus Glycoprotein B Variants
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15040979
Abstract: Viruses can induce the fusion of infected and neighboring cells, leading to the formation of syncytia. Cell–cell fusion is mediated by viral fusion proteins on the plasma membrane of infected cells that interact with cellular… read more here.
Keywords: fusogenicity; system; cell; fusion ... See more keywords
Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.79077
Abstract: Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca2+ channels, and direct neurotransmitter release toward postsynaptic receptor domains.… read more here.
Keywords: fusogenicity; active zone; rim elks; munc13 supports ... See more keywords