The role of FUT8‐catalyzed core fucosylation in Alzheimer's amyloid‐β oligomer‐induced activation of human microglia
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DOI: 10.1002/glia.24345
Abstract: Fucosylation, especially core fucosylation of N‐glycans catalyzed by α1‐6 fucosyltransferase (fucosyltransferase 8 or FUT8), plays an important role in regulating the peripheral immune system and inflammation. However, its role in microglial activation is poorly understood.… read more here.
Keywords: fucosylation; activation; role; core fucosylation ... See more keywords
Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase
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DOI: 10.1038/s41467-020-14794-z
Abstract: Core-fucosylation is an essential biological modification by which a fucose is transferred from GDP-β-L-fucose to the innermost N-acetylglucosamine residue of N -linked glycans. A single human enzyme α1,6-fucosyltransferase (FUT8) is the only enzyme responsible for… read more here.
Keywords: fut8; modification; catalysis; substrate recognition ... See more keywords