Human germline editing: Insights to future clinical treatment of diseases
Sign Up to like & getrecommendations! Published in 2018 at "Protein & Cell"
DOI: 10.1007/s13238-018-0594-8
Abstract: 1 Key Laboratory for Major Obstetric Diseases of Guangdong Province, Center of Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China 2 Disease Modeling and Therapeutics Laboratory, A*STAR Institute of Molecular… read more here.
Keywords: insights future; medicine; editing insights; future clinical ... See more keywords
The Future of Clinical Research
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Investigative Medicine"
DOI: 10.1016/b978-0-12-802101-9.00043-0
Abstract: Publisher Summary Many studies at the cell or gene level may “translate” new information that increases the understanding of how biologic systems function and/or are regulated. Such research is clearly bench-type. Much useful information can… read more here.
Keywords: research; patient oriented; information; por ... See more keywords
CRB1-associated retinal dystrophies: a prospective natural history study in anticipation of future clinical trials.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2021.07.021
Abstract: PURPOSE To describe the natural disease course of CRB1-associated retinal dystrophies, and to identify clinical endpoints for future clinical trials. DESIGN Single center, prospective case series. METHODS An investigator-initiated nationwide collaborative study that included 22… read more here.
Keywords: retinal dystrophies; associated retinal; future clinical; crb1 associated ... See more keywords
COVID-19 and the future of clinical epidemiology
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Epidemiology"
DOI: 10.1016/j.jclinepi.2021.07.009
Abstract: Clinical epidemiology, the “basic science for clinical medicine” 1 , has changed substantially over the last fifty years, moving its focus from clinician driven research and clinical settings to large cohorts and trials, NIH funding,… read more here.
Keywords: epidemiology covid; clinical epidemiology; future clinical; epidemiology ... See more keywords
Chemical compound-based direct reprogramming for future clinical applications
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20171650
Abstract: Recent studies have revealed that a combination of chemical compounds enables direct reprogramming from one somatic cell type into another without the use of transgenes by regulating cellular signaling pathways and epigenetic modifications. The generation… read more here.
Keywords: cell; direct reprogramming; chemical compound; future clinical ... See more keywords
Desmoplastic small round cell tumor: from state of the art to future clinical prospects
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2023.2200171
Abstract: ABSTRACT Introduction Desmoplastic small round cell tumor (DSRCT) is an extremely rare and highly aggressive soft tissue sarcoma, presenting mainly in male adolescents and young adults with multiple nodules disseminated within the abdominopelvic cavity. Despite… read more here.
Keywords: cell tumor; desmoplastic small; round cell; small round ... See more keywords
Forecasting the future clinical events of a patient through contrastive learning
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Medical Informatics Association : JAMIA"
DOI: 10.1093/jamia/ocac086
Abstract: OBJECTIVE Deep learning models for clinical event forecasting (CEF) based on a patient's medical history have improved significantly over the past decade. However, their transition into practice has been limited, particularly for diseases with very… read more here.
Keywords: number positive; training instances; contrastive learning; forecasting future ... See more keywords
Medical school grades may predict future clinical competence
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000782
Abstract: Background: In real-world medical education, there is a lack of reliable predictors of future clinical competencies. Hence, we aim to identify the factors associated with clinical competencies and construct a prediction model to identify “improvement… read more here.
Keywords: medical school; school grades; clinical competencies; improvement required ... See more keywords
Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0194266
Abstract: The RV144 Phase III clinical trial with ALVAC-HIV prime and AIDSVAX B/E subtypes CRF01_AE (A244) and B (MN) gp120 boost vaccine regime in Thailand provided a foundation for the future development of improved vaccine strategies… read more here.
Keywords: protein; hiv; gp120; potent adjuvant ... See more keywords
Is Digital Epidemiology the Future of Clinical Epidemiology?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Epidemiology and Global Health"
DOI: 10.2991/jegh.k.190314.003
Abstract: *Correspondence: [email protected] Clinical epidemiology is conventionally defined as a type of research focused on dissecting the impact of precursors, causes, or courses of diseases in the general population [1]. Its ultimate scope is promoting better… read more here.
Keywords: digital epidemiology; epidemiology future; clinical epidemiology; future clinical ... See more keywords
Clinical Reasoning in Cardiology: Past, Present and Future.
Sign Up to like & getrecommendations! Published in 2022 at "Arquivos brasileiros de cardiologia"
DOI: 10.36660/abc.20220002
Abstract: Clinical reasoning was born 2,500 years ago with Hippocrates, having evolved over the centuries, becoming a mixture of art and science. Several personalities throughout history have contributed to improving diagnostic accuracy. Nonetheless, diagnostic error is… read more here.
Keywords: future clinical; clinical reasoning; cardiology; reasoning cardiology ... See more keywords