Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1450-8568
Abstract: Clinical parameters have been extensively studied in factor (F) VII deficiency, but the knowledge of molecular mechanisms of this disease is scarce. We report on three probands with intracranial bleeds at early age, one of… read more here.
Keywords: fvii; molecular characterization; factor vii; characterization two ... See more keywords
Adipocytes express tissue factor and FVII and are procoagulant in a TF/FVIIa-dependent manner
Sign Up to like & getrecommendations! Published in 2019 at "Upsala Journal of Medical Sciences"
DOI: 10.1080/03009734.2019.1645248
Abstract: Abstract Background: Tissue factor (TF) combined with its ligand FVII initiates blood coagulation and intracellular signaling. Obese and type 2 diabetic subjects have increased TF expression in their adipose tissue and an increased risk for… read more here.
Keywords: fvii; fviia; fviia dependent; tissue factor ... See more keywords
Novel IVS7+1G>T mutation of life-threatening congenital factor VII deficiency in neonates
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017360
Abstract: Abstract In neonates, congenital factor VII deficiency (FVIID) is characterized by central nervous system bleeding and gastrointestinal hemorrhage, often resulting in poor prognosis and high mortality. To improve understanding of FVIID in neonates in Asia,… read more here.
Keywords: factor; vii deficiency; fvii; factor vii ... See more keywords
Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-139219
Abstract: Introduction Congenital factor (F) VII deficiency is an inherited bleeding disorder with an autosomal recessive inheritance pattern. We report on two probands who had intracranial bleedings as toddlers. One of them had concomitant high titer… read more here.
Keywords: fvii; factor vii; microscopy; factor ... See more keywords