Engineering of a membrane-triggered activity switch in coagulation factor VIIa
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1618713114
Abstract: Significance Coagulation factor VIIa (FVIIa) is an intrinsically poor serine protease that requires assistance from its cofactor tissue factor (TF) to trigger the extrinsic pathway of blood coagulation. TF stimulates FVIIa through allosteric maturation of… read more here.
Keywords: factor viia; fviia; coagulation; membrane ... See more keywords
Adipocytes express tissue factor and FVII and are procoagulant in a TF/FVIIa-dependent manner
Sign Up to like & getrecommendations! Published in 2019 at "Upsala Journal of Medical Sciences"
DOI: 10.1080/03009734.2019.1645248
Abstract: Abstract Background: Tissue factor (TF) combined with its ligand FVII initiates blood coagulation and intracellular signaling. Obese and type 2 diabetic subjects have increased TF expression in their adipose tissue and an increased risk for… read more here.
Keywords: fvii; fviia; fviia dependent; tissue factor ... See more keywords
Direct Amplification of TF (Tissue Factor).
Sign Up to like & getrecommendations! Published in 2019 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.119.313215
Abstract: OBJECTIVE Regulation of TF (tissue factor):FVIIa (coagulation factor VIIa) complex procoagulant activity is especially critical in tissues where plasma can contact TF-expressing cells. One example is the liver, where hepatocytes are routinely exposed to plasma… read more here.
Keywords: fviia; procoagulant activity; activity; tissue factor ... See more keywords
Factor VIIa induces extracellular vesicles from the endothelium: A potential mechanism for its hemostatic effect.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020008417
Abstract: Recombinant FVIIa (rFVIIa) is used as a hemostatic agent to treat bleeding disorders in hemophilia patients with inhibitors and other groups of patients. Our recent studies showed that FVIIa binds endothelial cell protein C receptor… read more here.
Keywords: extracellular vesicles; fviia; par1; epcr ... See more keywords