Effect of dalteparin administration on thrombin generation kinetics in healthy dogs
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DOI: 10.1111/vcp.12489
Abstract: BACKGROUND Dalteparin is used to prevent thrombotic complications in dogs. Measurement of anti-factor Xa (anti-FXa) activity is currently used for monitoring therapy, but remains a nonfunctional test. The calibrated automated thrombogram (CAT) could be a… read more here.
Keywords: anti fxa; fxa activity; thrombin generation; healthy dogs ... See more keywords
Comparison of Second and First Generation of Andexanet Alfa in a Porcine Polytrauma Model with Apixaban Anticoagulation
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DOI: 10.1182/blood-2018-99-114542
Abstract: Background Andexanet alfa (AnXa; Andexxa) was developed as a specific antidote for direct and indirect factor Xa (FXa) inhibitors. It has been approved in the US for the reversal of apixaban and rivaroxaban anticoagulation when… read more here.
Keywords: anxa; anti fxa; fxa activity; generation ... See more keywords
Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model
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DOI: 10.1371/journal.pone.0195122
Abstract: Introduction Increasing use of factor Xa (FXa) inhibitors necessitates effective reversal agents to manage bleeding. Andexanet alfa, a novel modified recombinant human FXa, rapidly reverses the anticoagulation effects of direct and indirect FXa inhibitors. Objective… read more here.
Keywords: anticoagulation; fxa; andexanet; anti fxa ... See more keywords