Anti-inflammatory effect of factor-Xa inhibitors in Japanese patients with atrial fibrillation
Sign Up to like & getrecommendations! Published in 2017 at "Heart and Vessels"
DOI: 10.1007/s00380-017-0962-y
Abstract: Activated factor-X (FXa) plays an important role not only in the coagulation cascade, but also in pro-inflammatory responses. However, few data exist regarding the anti-inflammatory effect of FXa inhibitors in clinical practice. The aim of… read more here.
Keywords: anti inflammatory; fxa inhibitors; inflammatory effect; inhibitors japanese ... See more keywords
In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking
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DOI: 10.1007/s13659-017-0126-x
Abstract: Coagulation Factor Xa (FXa) is the crucial enzyme at the convergent point of the intrinsic and extrinsic coagulation pathways. The inhibition of FXa is an effective approach against thrombotic diseases. In the present study, a… read more here.
Keywords: fxa inhibitors; fxa; discovery novel; silico discovery ... See more keywords
Design, synthesis and biological evaluation of novel 2,3-dihydroquinazolin- 4(1H)-one derivatives as potential fXa inhibitors.
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DOI: 10.1016/j.ejmech.2016.09.055
Abstract: Coagulation factor Xa (fXa) is a particularly attractive target for the development of effective and safe anticoagulants. In this study, novel 2,3-dihydroquinazolin-4(1H)-one derivatives were designed as potential fXa inhibitors based on anthranilamide structure which has… read more here.
Keywords: fxa inhibitors; fxa; one derivatives; dihydroquinazolin one ... See more keywords
Contemporary medicinal-chemistry strategies for discovery of blood coagulation factor Xa inhibitors
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DOI: 10.1080/17460441.2019.1626821
Abstract: ABSTRACT Introduction: Thrombosis is a common causal pathology for stroke, acute coronary syndrome and venous thromboembolism disorders, which are the leading cause of death worldwide. Anticoagulants have exhibited a crucial role in the prevention and… read more here.
Keywords: fxa inhibitors; medicinal chemistry; chemistry; strategies discovery ... See more keywords
Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood: A diagnostic test study
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DOI: 10.1097/eja.0000000000000903
Abstract: BACKGROUND Rapid detection of the anticoagulant effect of oral factor Xa (FXa) inhibitors may be essential in several emergency clinical situations. Specific assays quantifying the drugs are performed in plasma and require a turnaround time… read more here.
Keywords: fxa inhibitors; blood; whole blood; modified rotem ... See more keywords
Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors.
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DOI: 10.1182/bloodadvances.2016003616
Abstract: Anticoagulants such as unfractionated heparin (UFH), low-molecular-weight heparins (LMWHs), fondaparinux, and direct oral anticoagulants (DOACs) targeting thrombin (IIa) or factor Xa (FXa) are widely used in prevention and treatment of thromboembolic disorders. However, anticoagulant-associated bleeding… read more here.
Keywords: fxa inhibitors; fxa; uhra andexanet; per977 ... See more keywords
Viscoelastometry for detecting oral anticoagulants
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DOI: 10.1186/s12959-021-00267-w
Abstract: Background Determination of anticoagulant therapy is of pronounced interest in emergency situations. However, routine tests do not provide sufficient insight. This study was performed to investigate the impact of anticoagulants on the results of viscoelastometric… read more here.
Keywords: fxa inhibitors; eca test; test; test test ... See more keywords
A Diagnostic Solution for Lupus Anticoagulant Testing in Patients Taking Direct Oral FXa Inhibitors Using DOAC Filter
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DOI: 10.3389/fmed.2021.683357
Abstract: Background: Direct oral factor Xa (FXa) inhibitors interfere with lupus anticoagulant (LA) assays challenging antiphospholipid syndrome diagnosis in treated patients. We evaluated a new device, called DOAC Filter, and its usefulness in this setting. It… read more here.
Keywords: fxa inhibitors; rivaroxaban apixaban; direct oral; doac filter ... See more keywords