Factor XI Inhibitors in Early Clinical Trials: A Meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-2043-0346
Abstract: BACKGROUND Phase II randomized controlled trials (RCTs) on factor(F)XI inhibitors have shown promising results but they were burdened by low statistical power for clinical outcomes. METHODS We performed a systematic review and meta-analysis of RCT… read more here.
Keywords: efficacy; factor inhibitors; fxi inhibitors; meta analysis ... See more keywords
Factor XI inhibitors: what should clinicians know
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DOI: 10.1097/hco.0000000000001015
Abstract: Purpose of review Factor XI (FXI) inhibitors were developed to address unmet needs and limitations of current anticoagulants and are currently being studied in several indications. In this paper, we review the rationale for the… read more here.
Keywords: inhibitors clinicians; fxi inhibitors; factor inhibitors; clinicians know ... See more keywords
Pharmacology and Clinical Development of Factor XI Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Circulation"
DOI: 10.1161/circulationaha.122.062353
Abstract: Therapeutic anticoagulation is indicated for a variety of circumstances and conditions in several fields of medicine to prevent or treat venous and arterial thromboembolism. According to the different mechanisms of action, the available parenteral and… read more here.
Keywords: phase studies; pharmacology; fxi inhibitors; factor ... See more keywords