New Triazole-Based Potent Inhibitors of Human Factor XIIa as Anticoagulants
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DOI: 10.1021/acsomega.3c09335
Abstract: Factor XIIa (FXIIa) functions as a plasma serine protease within the contact activation pathway. Various animal models have indicated a substantial role for FXIIa in thromboembolic diseases. Interestingly, individuals and animals with FXII deficiency seem… read more here.
Keywords: factor xiia; triazole based; inhibitors human; fxiia ... See more keywords
Scaffold stability and P14′ residue steric hindrance in the differential inhibition of FXIIa by Aedes aegypti trypsin inhibitor versus Infestin-4
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20220421
Abstract: Abstract Kazal-type protease inhibitors strictly regulate Factor XIIa (FXIIa), a blood-clotting serine protease. However, when negatively charged surface of prosthetic device come into contact with FXII, it undergoes conformational change and auto-activation, leading to thrombus… read more here.
Keywords: protease; inhibitor; fxiia; site ... See more keywords