Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3326-8
Abstract: Factor XIII (FXIII) stabilizes and protects the fibrin network. Its role in myocardial infarction (MI) is still to be clarified. To evaluate the association of FXIII levels with MI in young patients and to investigate… read more here.
Keywords: fxiii; risk; young patients; myocardial infarction ... See more keywords
Transglutaminase Activities of Blood Coagulant Factor XIII Are Dependent on the Activation Pathways and on the Substrates
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-1993-4193
Abstract: Factor XIII (FXIII) catalyzes formation of γ-glutamyl-ε-lysyl crosslinks between reactive glutamines (Q) and lysines (K). In plasma, FXIII is activated proteolytically (FXIII-A*) by the concerted action of thrombin and Ca2+. Cellular FXIII is activated non-proteolytically… read more here.
Keywords: factor xiii; fbg 233; fxiii; activation ... See more keywords
Antibodies against Noncatalytic B Subunit of Factor XIII Inhibit Activation of Factor XIII and Fibrin Crosslinking
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-2057-8710
Abstract: BACKGROUND Coagulation factor XIII (FXIII) is a proenzyme of plasma transglutaminase. It comprises two catalytic A subunits (FXIII-A) and two carrier B subunits (FXIII-B). We previously reported that alloantibodies against FXIII-B could promote FXIII clearance… read more here.
Keywords: factor xiii; fibrin crosslinking; fxiii; activation ... See more keywords
Binding of Coagulation Factor XIII Zymogen to Activated Platelet Subpopulations: Roles of Integrin αIIbβ3 and Fibrinogen.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0039-1683912
Abstract: Factor XIIIa (fXIIIa) is a transglutaminase that plays a crucial role in fibrin clot stabilization and regulation of fibrinolysis. It is known to bind to procoagulant platelets. In contrast, the zymogen fXIII interaction with platelets… read more here.
Keywords: fxiii; fibrinogen; platelet subpopulations; activated platelet ... See more keywords
Defective α2antiplasmin cross‐linking and thrombus stability in a case of acquired factor XIII deficiency
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14759
Abstract: Acquired factor XIII (FXIII) deficiency is a rare and life‐threatening condition that is often misdiagnosed or missed completely. A 72‐year‐old woman presented with symptoms of major unprovoked bleeding but routine coagulation screening tests and platelet… read more here.
Keywords: fxiii; factor xiii; acquired factor; cross ... See more keywords
Factor XIII: What does it look like?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14431
Abstract: Coagulation factor XIII (FXIII) is a stepchild among clotting factors. As opposed to all other zymogenic clotting factors, it is not the precursor of a proteolytic enzyme but of a transglutaminase. It is of tetrameric… read more here.
Keywords: fxiii; look like; factor; xiii look ... See more keywords
Patient-centered approach to managing factor XIII deficiency
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Case Reports"
DOI: 10.1136/bcr-2020-241501
Abstract: Factor XIII (FXIII) is a thrombin-activated protransglutaminase that plays a key role in blood clot formation. Congenital FXIII A-subunit deficiency represents a rare bleeding disorder that affects one in 2–3 million individuals worldwide and is treated… read more here.
Keywords: fxiii; patient centered; approach; factor xiii ... See more keywords
Spatial Structure of Plasma Coagulation Factor XIII and Changes with Activation
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-112806
Abstract: Introduction Blood coagulation factor XIII (FXIII) is a precursor of the active transglutaminase (FXIIIa) that catalyzes covalent cross-linking within polymeric fibrin to increase mechanical and proteolytic stability of blood clots and thrombi. Structurally, inactive plasma… read more here.
Keywords: fxiii; pfxiii a2b2; structure; thrombin ... See more keywords
A Novel Assay Using Enzyme Capture - ELISA for Accurate Determination of Factor XIII Activity
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-142811
Abstract: Background: The currently available, clinically approved factor XIII (fXIII) activity assays rely on indirect measurement of activated fXIII transglutaminase activity by detecting "ammonia-release" during an intermediate step of the reaction. Unfortunately, this assay is also… read more here.
Keywords: fxiii; capture elisa; enzyme capture; factor xiii ... See more keywords
The Structure of Blood Coagulation Factor XIII Is Adapted to Oxidation
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10060914
Abstract: The blood coagulation factor XIII (FXIII) plays a critical role in supporting coagulation and fibrinolysis due to both the covalent crosslinking of fibrin polymers, rendering them resistant to plasmin lysis, and the crosslinking of fibrin… read more here.
Keywords: fxiii; coagulation; factor xiii; oxidation ... See more keywords
Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063055
Abstract: Factor XIII (FXIII) is a transglutaminase enzyme that catalyses the formation of ε-(γ-glutamyl)lysyl isopeptide bonds into protein substrates. The plasma form, FXIIIA2B2, has an established function in haemostasis, with fibrin being its principal substrate. A… read more here.
Keywords: haemostasis wound; fxiii; wound healing; factor xiii ... See more keywords