FAST-1 antisense RNA epigenetically alters FXN expression
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35639-2
Abstract: Friedreich ataxia (FRDA) is a multisystem genetic disorder caused by GAA repeat expansion mutations within the FXN gene, resulting in heterochromatin formation and deficiency of frataxin protein. Elevated levels of the FXN antisense transcript (FAST-1)… read more here.
Keywords: fast frda; expression fast; expression; fxn expression ... See more keywords
Defining transcription regulatory elements in the human frataxin gene: implications for gene therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Human gene therapy"
DOI: 10.1089/hum.2020.053
Abstract: Friedreich's ataxia is the most common inherited form of ataxia in humans. It is caused by severe downregulation of Frataxin (FXN) expression instigated by hyperexpansion of the GAA repeats located in intron 1 of the… read more here.
Keywords: gene therapy; expression; fxn expression; gene ... See more keywords