Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32270
Abstract: BACKGROUND AND AIMS Iron overload is a frequent finding in the general population. As the major iron storage site, liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is… read more here.
Keywords: iron; iron overload; mice; fxr ... See more keywords
Probiotic‐derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32608
Abstract: Background and Aims: Intestinal farnesoid X receptor (FXR) plays a critical role in alcohol‐associated liver disease (ALD). We aimed to investigate whether alcohol‐induced dysbiosis increased intestinal microRNA194 (miR194) that suppressed Fxr transcription and whether Lactobacillus… read more here.
Keywords: intestinal mir194; alcohol; mir194; fxr activation ... See more keywords
Cholesterol-lowering effects of taurine through the reduction of ileal FXR signaling due to the alteration of ileal bile acid composition.
Sign Up to like & getrecommendations! Published in 2021 at "Amino acids"
DOI: 10.1007/s00726-021-03068-7
Abstract: Studies using animal models of hypercholesterolemia have established that taurine reduces cholesterol levels; however, the precise mechanism underlying this cholesterol-lowering effect is unclear. This study addressed this issue by investigating whether bile acid/farnesoid X receptor… read more here.
Keywords: fxr; cholesterol lowering; ileal; cholesterol ... See more keywords
FXR/TGR5 mediates inflammasome activation and host resistance to bacterial infection
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101051
Abstract: Bacterial infections are a major cause of chronic infections and mortality. Innate immune control is crucial for protection against bacterial pathogens. Bile acids facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through… read more here.
Keywords: fxr tgr5; infection; fxr; inflammasome activation ... See more keywords
Dioscin alleviates lung ischemia/reperfusion injury by regulating FXR-mediated oxidative stress, apoptosis, and inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174321
Abstract: Dioscin showed various pharmacological effects in our previous studies; however, the effects and mechanisms against lung ischemia/reperfusion injury (LI/RI) have not been reported. Hypoxia/reoxygenation (H/R) models were established using A549 and primary AEC-II cells, while… read more here.
Keywords: dioscin; fxr; apoptosis; inflammation ... See more keywords
Pleiotropic roles of FXR in liver and colorectal cancers
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111543
Abstract: Nuclear receptor farnesoid X receptor (FXR) is generally considered a cell protector of enterohepatic tissues and a suppressor of liver cancer and colorectal carcinoma (CRC). Loss or reduction of FXR expression occurs during carcinogenesis, and… read more here.
Keywords: cancer; pleiotropic roles; roles fxr; fxr ... See more keywords
Liraglutide inhibits gallstone formation.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2021.154728
Abstract: BACKGROUND & AIMS Cholesterol gallstone disease (CGD) is a common gastrointestinal disease. Liraglutide, an analog of glucagon-like peptide 1, has been approved to treat type 2 diabetes. Clinical studies have suggested a potential role of… read more here.
Keywords: fxr; cgd; cholesterol; liraglutide ... See more keywords
Cigarette smoke extract combined with LPS down-regulates the expression of MRP2 in chronic pulmonary inflammation may be related to FXR.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.06.019
Abstract: The transporter multidrug resistance protein 2 (MRP2) plays an important role in chronic pulmonary inflammation by transporting cigarette smoke and other related inflammatory mediators. However, it is not completely clear whether pulmonary inflammation caused by… read more here.
Keywords: fxr; pulmonary inflammation; cigarette smoke; inflammation ... See more keywords
Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation
Sign Up to like & getrecommendations! Published in 2018 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2018.04.025
Abstract: As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous… read more here.
Keywords: fxr; hippocampal fxr; system; pathogenesis depression ... See more keywords
Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111949
Abstract: Farnesoid X receptor (FXR) is a metabolic nuclear receptor, which protects liver from many endogenous and exogenous injuries. Metallothioneins (MTs) belong to a low-molecular-weight protein family involved in metal homeostasis and the regulation of hepatic… read more here.
Keywords: fxr; liver; expression; mouse ... See more keywords
20S-protopanaxatriol ameliorates hepatic fibrosis potentially involving of FXR-mediated inflammatory signaling cascades.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c01978
Abstract: Ginseng has been used as functional foods and tonic for enhancing immune power. Currently, the potential protective effect of 20S-protopanaxatriol (M4), the metabolites of protopanaxatriol, against hepatic fibrosis is investigated, which could supply nutritional interventions… read more here.
Keywords: fxr; fibrosis; 20s protopanaxatriol; hepatic fibrosis ... See more keywords