Probiotic‐derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32608
Abstract: Background and Aims: Intestinal farnesoid X receptor (FXR) plays a critical role in alcohol‐associated liver disease (ALD). We aimed to investigate whether alcohol‐induced dysbiosis increased intestinal microRNA194 (miR194) that suppressed Fxr transcription and whether Lactobacillus… read more here.
Keywords: intestinal mir194; alcohol; mir194; fxr activation ... See more keywords
FXR activation enhances ACE2 expression and inhibits viral-induced IL-6 release from colonic epithelial cells in vitro: implications for gastrointestinal symptoms of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733615
Abstract: Introduction: While better known for its pulmonary symptoms, SARS-CoV-2 also adversely affects the gastrointestinal tract, causing diarrhoea with evidence of inflammation. The nuclear bile acid receptor, farnesoid x receptor (FXR), is expressed in colonic epithelial… read more here.
Keywords: expression; physiology; fxr activation; epithelial cells ... See more keywords