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1
Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12629-4
Abstract: The nuclear receptor, farnesoid X receptor (FXR), has been recently considered as a tumor suppressor in HCC. IL-6/Janus kinase 2 (Jak-2)/signal transducer and activator of transcription 3 (STAT3) pathway has been implicated as a key…
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Keywords:
fxr agonist;
stat3;
obeticholic acid;
agonist obeticholic ... See more keywords
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Published in 2018 at "Gastroenterology"
DOI: 10.1053/j.gastro.2018.06.038
Abstract: Bile acid (BA) synthesis is regulated through suppression of hepatic cholesterol 7α-hydroxylase via farnesoid X receptor (FXR) activation in hepatocytes and/or enterocytes; in enterocytes, this process requires FGF19 signaling. To study these pathways, we quantified markers…
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Keywords:
fxr agonist;
serum levels;
acid synthesis;
bile acid ... See more keywords
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2
Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2217024
Abstract: ABSTRACT Colorectal cancer (CRC) is one of the top three malignant tumors in terms of morbidity, and the limited efficacy of existing therapies urges the discovery of potential treatment strategies. Immunotherapy gradually becomes a promising…
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Keywords:
crc;
colorectal cancer;
fxr agonist;
gw4064 ... See more keywords
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0
Published in 2020 at "Diabetes"
DOI: 10.2337/db20-1810-p
Abstract: Semaglutide (SEMA), FXR agonists and ACC inhibitors are under active clinical investigation for the treatment of NASH. Here, we explored whether the effects of SEMA (0.12 mg/kg, s.c., q.d.) on NASH endpoints could be enhanced…
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Keywords:
fxr agonist;
diet induced;
nash;
induced biopsy ... See more keywords
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2
Published in 2022 at "Molecules"
DOI: 10.3390/molecules27248968
Abstract: Acetaminophen (APAP) toxicity is a common cause of hepatic failure, and the development of effective therapy is still urgently needed. Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has been identified as…
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Keywords:
fxr;
natural product;
product oxokolavenol;
fxr agonist ... See more keywords