Molecular tuning of farnesoid X receptor partial agonism
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DOI: 10.1038/s41467-019-10853-2
Abstract: The bile acid-sensing transcription factor farnesoid X receptor (FXR) regulates multiple metabolic processes. Modulation of FXR is desired to overcome several metabolic pathologies but pharmacological administration of full FXR agonists has been plagued by mechanism-based… read more here.
Keywords: partial agonism; fxr; fxr agonists; farnesoid receptor ... See more keywords