Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00534
Abstract: Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR… read more here.
Keywords: fxr; fxr antagonists; discovery new; oxadiazole core ... See more keywords
Discovery of 9,11-Seco-Cholesterol Derivatives as Novel FXR Antagonists
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DOI: 10.1021/acsomega.2c01567
Abstract: The farnesoid X receptor (FXR) plays an important role in the regulation of bile acid, lipid, and glucose homeostasis. Recent findings have shown that the inhibition of FXR is beneficial to improvement of related metabolic… read more here.
Keywords: discovery seco; seco cholesterol; derivatives novel; fxr antagonists ... See more keywords
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062840
Abstract: Compounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary… read more here.
Keywords: farnesoid receptor; oxadiazole derivatives; receptor fxr; fxr antagonists ... See more keywords