Polygonum multiflorum Thunb suppress bile acid synthesis by activating Fxr-Fgf15 signaling in the intestine.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.12.007
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Polygonum multiflorum Thunb (Heshouwu, HSW) is commonly used in clinical medicine, while the hepatotoxicities of HSW are reported increasingly in recent years. Currently, researchers have demonstrated an essential role of Bile Acids (BAs)… read more here.
Keywords: polygonum multiflorum; multiflorum thunb; hsw; fxr fgf15 ... See more keywords
Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway
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DOI: 10.1155/2022/4919153
Abstract: Aim Chlorogenic acid (CGA) is a natural polyphenolic compound found in human dietary products. Previous studies have confirmed that CGA has many biological activities, such as regulating glucose and lipid metabolism and improving insulin resistance.… read more here.
Keywords: enterohepatic fxr; chlorogenic acid; fgf15 pathway; fxr fgf15 ... See more keywords
Repression of intestinal transporters and FXR-FGF15 signaling explains bile acids dysregulation in experimental colitis-associated colon cancer
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DOI: 10.18632/oncotarget.18885
Abstract: Bile acids (BAs) are important endogenous signaling molecules that play vital roles in the pathological development of various diseases including colitis-associated cancer (CAC). BAs were previously found dysregulated under conditions of CAC; however, the exact… read more here.
Keywords: bile acids; fxr fgf15; cac; colon ... See more keywords
Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis
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DOI: 10.3390/ijms23116046
Abstract: Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core attached to a hydroxyl group with a varying number, position, and orientation, and a hydrophilic side chain. While BAs act… read more here.
Keywords: acid fxr; fxr fgf15; basis bile; molecular basis ... See more keywords