Liquiritin alleviates alpha‐naphthylisothiocyanate‐induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4385
Abstract: Liquiritin (LQ) is an important monomer active component in flavonoids of licorice. The objective of this study was to evaluate the hepatoprotective effects of LQ in cholestatic mice. LQ (40 or 80 mg/kg) was intragastrically administered… read more here.
Keywords: liquiritin; fxr nrf2; sirt1 fxr; expression ... See more keywords
Potential therapeutic action of Tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical science"
DOI: 10.1042/cs20220674
Abstract: Cholestasis is a pathophysiologic syndrome with limited therapeutic options. Tauroursodeoxycholic acid (TUDCA) has been employed to treat hepatobiliary disorders and is as effective as UDCA in alleviating cholestatic liver disease in clinical trials. Until now,… read more here.
Keywords: cholestasis; liver injury; fxr nrf2; fxr ... See more keywords