FXR Signaling-Mediated Bile Acid Metabolism Is Critical for Alleviation of Cholesterol Gallstones by Lactobacillus Strains
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00518-22
Abstract: Cholesterol gallstone (CGS) disease is prevalent worldwide. None of the medical options for prevention and treatment of CGS disease are recommended, and surgical management has a high rate of recurrence. ABSTRACT Cholesterol gallstone (CGS) disease… read more here.
Keywords: cgs; plantarum; gut; reuteri ... See more keywords
Loss of FXR Signaling Promotes Chronic Liver Injury in Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-143330
Abstract: Hepatic crisis is an emergent complication affecting sickle cell disease (SCD) patients, however, the molecular mechanism of sickle cell hepatobiliary crisis remains poorly understood. We have used intravital imaging to show that sinusoidal ischemia occurs… read more here.
Keywords: fxr signaling; scd mice; liver injury; injury ... See more keywords
Targeting the Gut MicrobiotaâFXR Signaling Axis for Glycemic Control: Does a Dietary Supplement Work Magic?
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes"
DOI: 10.2337/dbi16-0066
Abstract: Glucose-dependent organs such as the brain are sustained through periods of fasting by glucose production in the liver, called hepatic gluconeogenesis. Normally, rising blood glucose levels homeostatically suppress gluconeogenesis. In obesity-related type 2 diabetes, however,… read more here.
Keywords: fxr; signaling axis; fxr signaling; liver ... See more keywords