Fragile X-Related Protein 1 (FXR1) Promotes Trophoblast Migration at Early Pregnancy via Downregulation of GDF-15 Expression
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DOI: 10.1007/s43032-021-00693-1
Abstract: Fragile X-related protein 1 (FXR1) is an RNA-binding protein that can regulate specific mRNA decay in cells. Our previous study showed that FXR1 expression was significantly decreased in trophoblasts from patients with unexplained recurrent spontaneous… read more here.
Keywords: protein; fxr1; gdf; migration ... See more keywords
Abstract 1463: Fxr1 is an oncogenic driver in ovarian cancer
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DOI: 10.1158/1538-7445.am2023-1463
Abstract: Introduction: Ovarian cancer is primarily driven by copy number variations, mutations in p53, BRCA1 or BRCA2 genes. Using the single nucleotide polymorphism (SNP) array data of The Cancer Genome Atlas (TCGA), we identified that FXR1… read more here.
Keywords: cancer; translation; fxr1; ovarian cancer ... See more keywords
Evidence of an interaction between FXR1 and GSK3β polymorphisms on levels of Negative Symptoms of Schizophrenia and their response to antipsychotics
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DOI: 10.1192/j.eurpsy.2021.26
Abstract: Abstract Background Genome-Wide Association Studies (GWASs) have identified several genes associated with Schizophrenia (SCZ) and exponentially increased knowledge on the genetic basis of the disease. In addition, products of GWAS genes interact with neuronal factors… read more here.
Keywords: fxr1 gsk3; response antipsychotics; fxr1; interaction ... See more keywords