The role of FYCO1-dependent autophagy in lens fiber cell differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2025570
Abstract: ABSTRACT FYCO1 (FYVE and coiled-coil domain containing 1) is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles. We have previously shown that loss-of-function mutations in FYCO1 cause cataracts with… read more here.
Keywords: fyco1; microscopy; role fyco1; autophagy lens ... See more keywords
FYCO1 mediates clearance of α‐synuclein aggregates through a Rab7‐dependent mechanism
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DOI: 10.1111/jnc.14461
Abstract: Parkinson's disease can be caused by mutations in the α‐synuclein gene and is characterized by aggregates of α‐synuclein protein. We have previously shown that over‐expression of the small GTPase Rab7 can induce clearance of α‐synuclein… read more here.
Keywords: synuclein; synuclein aggregates; fyco1; clearance ... See more keywords
FYCO1 Frameshift Deletion in Wirehaired Pointing Griffon Dogs with Juvenile Cataract
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DOI: 10.3390/genes13020334
Abstract: Different breed-specific inherited cataracts have been described in dogs. In this study, we investigated an inbred family of Wirehaired Pointing Griffon dogs in which three offspring were affected by juvenile cataract. The pedigree suggested monogenic… read more here.
Keywords: fyco1; pointing griffon; juvenile cataract; griffon dogs ... See more keywords