NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16090
Abstract: BACKGROUND AND PURPOSE WNT binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation, and adult tissue homeostasis. Recent efforts… read more here.
Keywords: fzd7; wnt endogenous; pharmacology; colorectal cancer ... See more keywords
YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7
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DOI: 10.1158/0008-5472.can-20-0066
Abstract: This study provides a rationale for controlling translation of key oncogenic drivers in cancer by manipulating epigenetic regulators, representing a novel and efficient strategy for anticancer treatment. N6-methyladenosine (m6A) is the most prevalent internal RNA… read more here.
Keywords: translation; fzd7; cancer; gastric cancer ... See more keywords
Discovery of novel frizzled-7 inhibitors by targeting the receptor’s transmembrane domain
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DOI: 10.18632/oncotarget.20665
Abstract: Frizzled (Fzd) proteins are seven transmembrane receptors that belong to a novel and separated family of G-protein-coupled receptors (GPCRs). The Fzd receptors can respond to Wnt proteins to activate the canonical β-catenin pathway which is… read more here.
Keywords: cancer; fzd7; transmembrane domain; wnt fzd7 ... See more keywords
Anti-tumor activity of a recombinant soluble Fzd7 decoy receptor in human gastric and colon cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.61908.13700
Abstract: Objective(s): Frizzled-7, the most common receptor of the Wnt signaling pathway, was significantly over-expressed in gastric (GC) and colorectal (CRC) cancers and stimulated tumorigenesis. The extracellular domain of Fzd7 (sFzd7) as a decoy receptor, could… read more here.
Keywords: fzd7; colon cancer; decoy receptor; receptor ... See more keywords
FZD7, Regulated by Non-CpG Methylation, Plays an Important Role in Immature Porcine Sertoli Cell Proliferation
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DOI: 10.3390/ijms24076179
Abstract: The regulatory role of non-CpG methylation in mammals has been important in whole-genome bisulfite sequencing. It has also been suggested that non-CpG methylation regulates gene expression to affect the development and health of mammals. However,… read more here.
Keywords: fzd7; cpg methylation; non cpg; proliferation ... See more keywords