The CRD of Frizzled 7 exhibits chondroprotective effects in osteoarthritis via inhibition of the canonical Wnt3a/β-catenin signaling pathway.
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DOI: 10.1016/j.intimp.2020.106367
Abstract: Osteoarthritis (OA) is a chronic inflammatory joint disease without effective drugs. Frizzled 7 (FzD7) binds its ligand Wnt3a through an extracellular cysteine-rich domain (CRD) to transduce the canonical Wnt/β-catenin signaling pathway, which has been strongly… read more here.
Keywords: crd; fzd7 crd; catenin signaling; wnt3a catenin ... See more keywords