An E. coli‐produced single‐chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.12.019
Abstract: ABSTRACT Hepatitis B virus (HBV) envelopes as well as empty subviral particles carry in their lipid membranes the small (S), middle (M), and large (L) surface proteins, collectively known as hepatitis B surface antigen (HBsAg).… read more here.
Keywords: virion; g12 scfv; secretion; hepatitis ... See more keywords
A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection
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DOI: 10.1128/mbio.01612-22
Abstract: It is the first time that mRNA-LNPs have been used to express anti-HBsAg antibodies (G12-scFv, G12-scFv-Fc, and G12-IgG). G12-scFv-Fc- and G12-IgG-encoding mRNA-LNPs exerted a sustained effect on HBsAg serum clearance in the adeno-associated virus (AAV)/HBV… read more here.
Keywords: g12; hbsag; mrna lnps; scfv g12 ... See more keywords