G12V and G12C mutations in the gene KRAS are associated with a poorer prognosis in primary colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Colorectal Disease"
DOI: 10.1007/s00384-019-03344-9
Abstract: The increased incidence of colorectal cancer (CRC) has necessitated the development of novel prognostic and predictive factors from which new diagnostic tests could evolve. Evidence suggests the KRAS gene represents such a factor; its mutations… read more here.
Keywords: gene; g12v g12c; colorectal cancer; g12c mutations ... See more keywords
Abstract 12: Characterizing KRAS G12C and other mutations in plasma ctDNA from patients with lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.advprecmed20-12
Abstract: Background: KRAS is the most common oncogene in lung cancers, but despite decades of intense research, there are no FDA-approved drugs targeting these cancers. Recent recognition that KRAS G12C harbors a binding pocket near the… read more here.
Keywords: ctdna; non g12c; patients kras; cancer ... See more keywords