The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia
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DOI: 10.1016/j.isci.2022.103881
Abstract: Summary Mutations in RAS pathway genes are highly prevalent in acute lymphoblastic leukemia (ALL). However, the effects of RAS mutations on ALL cell growth have not been experimentally characterized, and effective RAS-targeting therapies are being… read more here.
Keywords: kras g12d; g12d mutation; acute lymphoblastic; lymphoblastic leukemia ... See more keywords
Oncogenic G12D mutation alters local conformations and dynamics of K-Ras
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DOI: 10.1038/s41598-019-48029-z
Abstract: K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of… read more here.
Keywords: mutation alters; local conformations; oncogenic g12d; g12d mutation ... See more keywords