In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens
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DOI: 10.7717/peerj.5056
Abstract: Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts… read more here.
Keywords: g13d; g12v g13d; sequence; silico guided ... See more keywords