Identification of potential inhibitors, conformational dynamics, and mechanistic insights into mutant Kirsten rat sarcoma virus (G13D) driven cancers
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DOI: 10.1002/jcb.30305
Abstract: The mutations at the hotspot region of K‐Ras result in the progression of cancer types. Our study aimed to explore the small molecule inhibitors against the G13D mutant K‐Ras model with anti‐cancerous activity from food… read more here.
Keywords: potential inhibitors; identification potential; driven cancers; conformational dynamics ... See more keywords
In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens
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DOI: 10.7717/peerj.5056
Abstract: Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts… read more here.
Keywords: g13d; g12v g13d; sequence; silico guided ... See more keywords