The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.07.012
Abstract: &NA; The G2019S mutation in LRRK2 is one of the most common known genetic causes of neurodegeneration and Parkinson disease (PD). LRRK2 mutations are thought to enhance LRRK2 kinase activity. Efficacious small molecule LRRK2 kinase… read more here.
Keywords: lrrk2 kinase; kinase; g2019s lrrk2; inhibition ... See more keywords
G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.08.018
Abstract: Fibrillization of α-synuclein is instrumental for the development of Parkinson's disease (PD), thus modulating this process can have profound impact on disease initiation/progression. Here, the impact of the p.G2019S mutation of leucine-rich repeat kinase 2… read more here.
Keywords: month old; g2019s lrrk2; syn; g2019s ... See more keywords
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1922184117
Abstract: Significance Parkinson’s disease (PD)-linked familial mutations in LRRK2 impact its enzymatic activity by commonly increasing kinase activity, either directly within the kinase domain or indirectly via the GTPase domain by impairing GTP hydrolysis. Familial LRRK2… read more here.
Keywords: kinase; g2019s lrrk2; kinase gtpase; lrrk2 ... See more keywords
Hierarchical Data-Driven Analysis of Clinical Symptoms Among Patients With Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2019.00531
Abstract: Mutations in the LRRK2 and GBA genes are the most common inherited causes of Parkinson's disease (PD). Studies exploring phenotypic differences based on genetic status used hypothesis-driven data-gathering and statistical-analyses focusing on specific symptoms, which… read more here.
Keywords: g2019s lrrk2; lrrk2 gba; data driven; parkinson disease ... See more keywords