LRRK2‐G2019S mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons
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DOI: 10.1111/jnc.15588
Abstract: The progressive degeneration of dopamine (DA) neurons in the substantia nigra compacta (SNc) leads to the emergence of motor symptoms in patients with Parkinson's disease (PD). To propose neuroprotective therapies able to slow or halt… read more here.
Keywords: synaptic transmission; glutamatergic synaptic; dopamine neurons; g2019s mice ... See more keywords
Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice
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DOI: 10.3390/biom12111635
Abstract: Pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are frequent causes of familial Parkinson’s Disease (PD), an increasingly prevalent neurodegenerative disease that affects basal ganglia circuitry. The cellular effects of the G2019S mutation… read more here.
Keywords: synaptic transmission; substantia nigra; lrrk2 g2019s; g2019s mice ... See more keywords
Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice
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DOI: 10.3390/biom13010051
Abstract: The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with late-onset Parkinson’s disease (PD). Although PD affects men and women differently, longitudinal studies examining sex- and age-dependent alterations in mice carrying… read more here.
Keywords: behavioral neurochemical; age; g2019s mice; sex ... See more keywords