Gaining insight into crizotinib resistance mechanisms caused by L2026M and G2032R mutations in ROS1 via molecular dynamics simulations and free-energy calculations
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DOI: 10.1007/s00894-017-3314-z
Abstract: AbstractROS1 fusion kinase—highly expressed in a variety of human cancers—has emerged as an important and attractive target for anticancer drug design. Crizotinib, a well-known drug approved by the FDA as an ALK inhibitor to treat… read more here.
Keywords: molecular dynamics; crizotinib; l2026m g2032r; resistance ... See more keywords