The AIRE G228W mutation disturbs the interaction of AIRE with its partner molecule SIRT1
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DOI: 10.3389/fimmu.2022.948419
Abstract: The autoimmune regulator (AIRE) protein functions as a tetramer, interacting with partner proteins to form the “AIRE complex,” which relieves RNA Pol II stalling in the chromatin of medullary thymic epithelial cells (mTECs). AIRE is… read more here.
Keywords: sand domain; sirt1; aire; g228w mutation ... See more keywords