CBIO-21. H3F3A G34R/V MUTATIONS INDUCE CHROMOSOMAL INSTABILITY AND PROMOTE PEDIATRIC HIGH-GRADE GLIOMA FORMATION
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DOI: 10.1093/neuonc/noaa215.081
Abstract: Histone H3.3 G34R/V mutations are drivers of pediatric high-grade glioma (pHGG). However, the mechanism(s) responsible for G34R/V induced tumorigenesis are unclear. We observed that pHGG cells with H3.3 G34 mutations have significantly reduced phosphorylation at… read more here.
Keywords: g34r mutations; g34r; glioma; high grade ... See more keywords
TMIC-62. INVESTIGATING THE ROLE OF OSTEOPONTIN IN RADIORESISTANCE OF H3.3-G34R PEDIATRIC HIGH-GRADE GLIOMA
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DOI: 10.1093/neuonc/noae165.1240
Abstract: Pediatric high-grade gliomas (pHGGs) are currently the leading cause of cancer-related deaths in children. Around 15% of pHGGs harbor a glycine to arginine (G34R) mutation in histone H3.3. Gliomas in general, including H3.3-G34R gliomas, contain… read more here.
Keywords: role; high grade; tumor; radioresistance ... See more keywords