ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507254
Abstract: The overexpression of ALKBH5 alleviates damage to cardiomyocytes and tissues, decreases the expression of SLC7A11, and inhibits the expression of p53N/T and ferroptosis. ALKBH5 induces ferroptosis in the HH/R model by mutating the 3′‐UTR of… read more here.
Keywords: alkbh5; 142 173; p53; g3bp1 ... See more keywords
G3bp1 - microRNA-1 axis regulates cardiomyocyte hypertrophy.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2022.110245
Abstract: Adaptation of gene expression is one of the most fundamental response of cardiomyocytes to hypertrophic stimuli. G3bp1, an RNA binding protein with site-specific endoribonuclease activity regulates the processing of pre-miR-1 stem-loop, and thus levels of… read more here.
Keywords: cardiomyocyte hypertrophy; g3bp1; gene expression; hypertrophy ... See more keywords
RNF144A-VRK2-G3BP1 axis regulates stress granule assembly
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02460-6
Abstract: Under the cellular stress, stress granules (SGs) help survival and proliferation of the cell. Unfortunately, the same SGs help unwanted cancer cells under stressful environment, including anti-cancer chemotherapy treatment. While SGs elevate the cancer cell’s… read more here.
Keywords: cancer; rnf144a vrk2; g3bp1 axis; axis regulates ... See more keywords
The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac473
Abstract: Abstract Polyglutamine diseases are a group of neurodegenerative disorders caused by an abnormal expansion of CAG repeat tracts in the codifying regions of nine, otherwise unrelated, genes. While the protein products of these genes are… read more here.
Keywords: stress; protein g3bp1; g3bp1; polyglutamine ... See more keywords
Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH
Sign Up to like & getrecommendations! Published in 2023 at "Open Biology"
DOI: 10.1098/rsob.220369
Abstract: G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formation,… read more here.
Keywords: caprin binding; caprin; g3bp1; binding critical ... See more keywords
A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-3454
Abstract: Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that the cytosolic lncRNA P53RRA is downregulated in cancers… read more here.
Keywords: p53rra; g3bp1; cancer; p53 ... See more keywords
Abstract 3073: Gene Regulation By RNP Granule Formation In Atherosclerosis
Sign Up to like & getrecommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvb.44.suppl_1.3073
Abstract: Background: Atherosclerosis, the leading cause of cardiovascular disease related death, is a chronic inflammatory condition incited by the accumulation of low-density lipoproteins (LDL) and recruitment of macrophages in the arterial intima. Macrophages become lipid laden… read more here.
Keywords: atherosclerosis; plaque; abstract 3073; g3bp1 ... See more keywords
TDRD3 is an antiviral restriction factor that promotes IFN signaling with G3BP1
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010249
Abstract: Stress granules (SGs) are highly dynamic cytoplasmic foci that form in response to activation of the integrated stress response (ISR) that results in eIF2α phosphorylation and global translation shutdown. Stress granules, which are largely nucleated… read more here.
Keywords: tdrd3 antiviral; g3bp1; tdrd3; evidence tdrd3 ... See more keywords
G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s213728
Abstract: Background GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is involved in various biological functions, including cell growth, metastasis, differentiation, apoptosis, and RNA metabolism. In current study, we aimed to investigate the effect of G3BP1 on… read more here.
Keywords: tgf smad; g3bp1; smad signaling; gastric cancer ... See more keywords
Critical role of G3BP1 in bovine parainfluenza virus type 3 (BPIV3)-inhibition of stress granules formation and viral replication.
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in immunology"
DOI: 10.3389/fimmu.2024.1358036
Abstract: Background It remains unclear whether BPIV3 infection leads to stress granules formation and whether G3BP1 plays a role in this process and in viral replication. This study aims to clarify the association between BPIV3 and… read more here.
Keywords: viral replication; g3bp1; bpiv3; stress granules ... See more keywords
Porcine Circovirus Type 3 Cap Inhibits Type I Interferon Induction Through Interaction With G3BP1
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2020.594438
Abstract: Porcine circovirus 3 (PCV3) infections cause clinical diseases similar to those seen in porcine circovirus 2 (PCV2) infections. It is unclear whether PCV3 infections can also cause immunosuppression like that seen with PCV2. Here, we… read more here.
Keywords: porcine circovirus; g3bp1; cap; interaction ... See more keywords