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   Articles with "g4c2 exp" as a keyword



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The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.

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recommendations! Published in 2019 at "Cell chemical biology"

DOI: 10.1016/j.chembiol.2018.10.018

Abstract: The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an expanded G4C2 repeat [(G4C2)exp] in C9ORF72. ALS/FTD-associated toxicity has been traced to the RNA transcribed from the repeat expansion… read more here.

Keywords: associated non; g4c2 exp; g4c2; repeat associated ... See more keywords
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Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies.

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recommendations! Published in 2023 at "Nucleic acids research"

DOI: 10.1093/nar/gkad403

Abstract: G4C2 and G2C4 repeat expansions in chromosome 9 open reading frame 72 (C9orf72) are the most common cause of genetically defined amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), or c9ALS/FTD. The gene is bidirectionally… read more here.

Keywords: repeat expansions; conformational dynamics; g2c4 repeat; g2c4 ... See more keywords