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   Articles with "g4s" as a keyword



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Purification and Characterisation of κ-Carrageenan Oligosaccharides Prepared by κ-Carrageenase from Thalassospira sp. Fjfst-332.

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recommendations! Published in 2018 at "Carbohydrate polymers"

DOI: 10.1016/j.carbpol.2017.10.043

Abstract: κ-Carrageenan oligosaccharides (KCOs) are promising agents for treating inflammatory diseases. However, the lack of purification and structural elucidation of KCOs has limited structure-function evaluation. In this study, using a system coupling medium pressure liquid chromatography… read more here.

Keywords: g4s g4sr; characterisation carrageenan; purification characterisation; g4s ... See more keywords

Transcription-facilitating histone chaperons interact with genomic and synthetic G4 structures.

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recommendations! Published in 2020 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2020.05.173

Abstract: Affinity for G-quadruplex (G4) structures may be a common feature of transcription-facilitating histone chaperons (HCs). This assumption is based on previous unmatched studies of HCs FACT, nucleolin (NCL), BRD3, and ATRX. We verified this assumption… read more here.

Keywords: facilitating histone; transcription; transcription facilitating; histone chaperons ... See more keywords

The Emerging Roles of Multimolecular G-Quadruplexes in Transcriptional Regulation and Chromatin Organization

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recommendations! Published in 2024 at "Accounts of Chemical Research"

DOI: 10.1021/acs.accounts.4c00574

Abstract: Conspectus The ability of genomic DNA to adopt non-canonical secondary structures known as G-quadruplexes (G4s) under physiological conditions has been recognized for its potential regulatory function of various biological processes. Among those, transcription has recently… read more here.

Keywords: formation; transcriptional regulation; chromatin; g4s ... See more keywords

Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine-Peptide Conjugate.

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recommendations! Published in 2020 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.0c00774

Abstract: Stabilization of G-quadruplexes (G4s) formed in guanine-rich (G-rich) nucleic acids by small-molecule ligands has been extensively explored as a therapeutic approach for diseases such as cancer. Finding ligands with sufficient affinity and specificity towards G4s… read more here.

Keywords: guanine; stabilization; bearing quadruplexes; vacancy bearing ... See more keywords

Cockayne Syndrome B Protein Selectively Resolves and Interact with Intermolecular DNA G-Quadruplex Structures.

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recommendations! Published in 2021 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.1c10745

Abstract: Guanine-rich DNA can fold into secondary structures known as G-quadruplexes (G4s). G4s can form from a single DNA strand (intramolecular) or from multiple DNA strands (intermolecular), but studies on their biological functions have been often… read more here.

Keywords: dna; cockayne syndrome; g4s; csb ... See more keywords

A core extended naphtalene diimide G-quadruplex ligand potently inhibits herpes simplex virus 1 replication

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-02667-3

Abstract: G-quadruplexes (G4s) are nucleic acids secondary structures, epigenetic regulators in cells and viruses. In herpes simplex virus 1 (HSV-1)-infected cells, G4s are massively present during viral replication. We here aimed at investigating the possibility to… read more here.

Keywords: hsv g4s; hsv; herpes simplex; g4s ... See more keywords

Opportunities and challenges with G-quadruplexes as promising targets for drug design

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recommendations! Published in 2024 at "Expert Opinion on Drug Discovery"

DOI: 10.1080/17460441.2024.2404230

Abstract: ABSTRACT Introduction G-quadruplexes (G4s) are secondary structures formed in guanine-rich regions of nucleic acids (both DNA and RNA). G4s are significantly enriched at regulatory genomic regions and are associated with important biological processes ranging from… read more here.

Keywords: challenges quadruplexes; g4s; drug; promising targets ... See more keywords

RPA engages telomeric G-quadruplexes more effectively than CST.

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recommendations! Published in 2023 at "Nucleic acids research"

DOI: 10.1093/nar/gkad315

Abstract: Abstract G-quadruplexes (G4s) are a set of stable secondary structures that form within guanine-rich regions of single-stranded nucleic acids that pose challenges for DNA maintenance. The G-rich DNA sequence at telomeres has a propensity to… read more here.

Keywords: rpa engages; quadruplexes effectively; telomeric quadruplexes; rpa ... See more keywords

Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf678

Abstract: Abstract G-quadruplex DNA structures (G4s) form within single-stranded DNA in nucleosome-free chromatin. G4s modulate gene expression and genomic stability, so high-throughput, genome-wide mapping of G4s has generated strong research interest and methodological innovation. Recently, the… read more here.

Keywords: targeted cut; cut tag; g4s; untargeted cut ... See more keywords
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Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky307

Abstract: Abstract The identification of four-stranded G-quadruplexes (G4s) has highlighted the fact that DNA has additional spatial organisations at its disposal other than double-stranded helices. Recently, it became clear that the formation of G4s is not… read more here.

Keywords: g4s; cytosine bulge; hydrodynamics; structure ... See more keywords

Unraveling the role of DNA G-quadruplexes in transcription in the rice.

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recommendations! Published in 2022 at "Plant physiology"

DOI: 10.1093/plphys/kiab599

Abstract: Guanine-rich regions of DNA can fold into a particular structure called a G-quadruplex (G4) (Figure 1, A). The G4 structure is stabilized by Hoogsteen hydrogen bonds that form between the guanine bases (Moon et al.,… read more here.

Keywords: dna; role; transcription; rice ... See more keywords