Purification and Characterisation of κ-Carrageenan Oligosaccharides Prepared by κ-Carrageenase from Thalassospira sp. Fjfst-332.
Sign Up to like & getrecommendations! Published in 2018 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.10.043
Abstract: κ-Carrageenan oligosaccharides (KCOs) are promising agents for treating inflammatory diseases. However, the lack of purification and structural elucidation of KCOs has limited structure-function evaluation. In this study, using a system coupling medium pressure liquid chromatography… read more here.
Keywords: g4s g4sr; characterisation carrageenan; purification characterisation; g4s ... See more keywords
Transcription-facilitating histone chaperons interact with genomic and synthetic G4 structures.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.05.173
Abstract: Affinity for G-quadruplex (G4) structures may be a common feature of transcription-facilitating histone chaperons (HCs). This assumption is based on previous unmatched studies of HCs FACT, nucleolin (NCL), BRD3, and ATRX. We verified this assumption… read more here.
Keywords: facilitating histone; transcription; transcription facilitating; histone chaperons ... See more keywords
Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine-Peptide Conjugate.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c00774
Abstract: Stabilization of G-quadruplexes (G4s) formed in guanine-rich (G-rich) nucleic acids by small-molecule ligands has been extensively explored as a therapeutic approach for diseases such as cancer. Finding ligands with sufficient affinity and specificity towards G4s… read more here.
Keywords: guanine; stabilization; bearing quadruplexes; vacancy bearing ... See more keywords
Cockayne Syndrome B Protein Selectively Resolves and Interact with Intermolecular DNA G-Quadruplex Structures.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c10745
Abstract: Guanine-rich DNA can fold into secondary structures known as G-quadruplexes (G4s). G4s can form from a single DNA strand (intramolecular) or from multiple DNA strands (intermolecular), but studies on their biological functions have been often… read more here.
Keywords: dna; cockayne syndrome; g4s; csb ... See more keywords
A core extended naphtalene diimide G-quadruplex ligand potently inhibits herpes simplex virus 1 replication
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02667-3
Abstract: G-quadruplexes (G4s) are nucleic acids secondary structures, epigenetic regulators in cells and viruses. In herpes simplex virus 1 (HSV-1)-infected cells, G4s are massively present during viral replication. We here aimed at investigating the possibility to… read more here.
Keywords: hsv g4s; hsv; herpes simplex; g4s ... See more keywords
RPA engages telomeric G-quadruplexes more effectively than CST.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad315
Abstract: Abstract G-quadruplexes (G4s) are a set of stable secondary structures that form within guanine-rich regions of single-stranded nucleic acids that pose challenges for DNA maintenance. The G-rich DNA sequence at telomeres has a propensity to… read more here.
Keywords: rpa engages; quadruplexes effectively; telomeric quadruplexes; rpa ... See more keywords
Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky307
Abstract: Abstract The identification of four-stranded G-quadruplexes (G4s) has highlighted the fact that DNA has additional spatial organisations at its disposal other than double-stranded helices. Recently, it became clear that the formation of G4s is not… read more here.
Keywords: g4s; cytosine bulge; hydrodynamics; structure ... See more keywords
Unraveling the role of DNA G-quadruplexes in transcription in the rice.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiab599
Abstract: Guanine-rich regions of DNA can fold into a particular structure called a G-quadruplex (G4) (Figure 1, A). The G4 structure is stabilized by Hoogsteen hydrogen bonds that form between the guanine bases (Moon et al.,… read more here.
Keywords: dna; role; transcription; rice ... See more keywords
G-Quadruplex Structures Colocalize with Transcription Factories and Nuclear Speckles Surrounded by Acetylated and Dimethylated Histones H3
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041995
Abstract: G-quadruplexes (G4s) are four-stranded helical structures that regulate several nuclear processes, including gene expression and telomere maintenance. We observed that G4s are located in GC-rich (euchromatin) regions and outside the fibrillarin-positive compartment of nucleoli. Genomic… read more here.
Keywords: nuclear speckles; quadruplex structures; structures colocalize; transcription factories ... See more keywords
Study on the Interaction of a Peptide Targeting Specific G-Quadruplex Structures Based on Chromatographic Retention Behavior
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021438
Abstract: G-quadruplexes (G4s) are of vital biological significance and G4-specific ligands with conformational selectivity show great application potential in disease treatment and biosensing. RHAU, a RNA helicase associated with AU-rich element, exerts biological functions through the… read more here.
Keywords: rhau peptide; chromatographic retention; parallel g4s; study interaction ... See more keywords
Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15050548
Abstract: In mammalian cells, telomerase transcribes telomeres in large G-rich non-coding RNA, known as telomeric repeat-containing RNA (TERRA), which folds into noncanonical nucleic acid secondary structures called G-quadruplexes (G4s). Since TERRA G4 has been shown to… read more here.
Keywords: chromene derivatives; selective terra; derivatives selective; rna ... See more keywords