The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein
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DOI: 10.1038/s41467-021-26433-2
Abstract: α-Synuclein (α-Syn) can form different fibril strains with distinct polymorphs and neuropathologies, which is associated with the clinicopathological variability in synucleinopathies. How different α-syn fibril strains are produced and selected under disease conditions remains poorly… read more here.
Keywords: fibril strain; g51d; fibril; hereditary mutation ... See more keywords