Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136077
Abstract: Fibril formation and aggregation of α-synuclein are important for the pathogenesis of neurodegenerative disorders including Parkinson's disease. In familial Parkinson's disease, the G51D mutation of α-synuclein causes severe symptoms and rapid progression. α-Synuclein, an intrinsically… read more here.
Keywords: g51d synuclein; g51d mutation; synuclein monomer; synuclein ... See more keywords
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041293
Abstract: A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related disorders; therefore, identification of the… read more here.
Keywords: mutation alpha; g51d mutation; pathological g51d; toxicity ... See more keywords