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Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity

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Published in 2021 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2021.136077

Abstract: Fibril formation and aggregation of α-synuclein are important for the pathogenesis of neurodegenerative disorders including Parkinson's disease. In familial Parkinson's disease, the G51D mutation of α-synuclein causes severe symptoms and rapid progression. α-Synuclein, an intrinsically… read more here.

Keywords: g51d synuclein; g51d mutation; synuclein monomer; synuclein ... See more keywords