METTL14‐Induced M6A Methylation Increases G6pc Biosynthesis, Hepatic Glucose Production and Metabolic Disorders in Obesity
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202417355
Abstract: METTL14 dimerizes with METTL3 to install N6‐methyladenosine (m6A) on mRNA (m6A writers). Subsequently, m6A readers bind to m6A‐marked RNA to influence its metabolism. RNA m6A emerges to critically regulate multiple intracellular processes; however, there is… read more here.
Keywords: hepatic glucose; m6a; g6pc; mettl14 ... See more keywords
The FOXO1/G6PC axis promotes gastric cancer progression and mediates 5‐fluorouracil resistance by targeting the PI3K/AKT/mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23681
Abstract: Gastric cancer (GC) is a prevalent malignancy of the digestive system. Distant metastasis and chemotherapy resistance are the crucial obstacles to prognosis in GC. Recent research has discovered that the glucose‐6‐phosphatase catalytic subunit (G6PC) plays… read more here.
Keywords: resistance; g6pc; foxo1 g6pc; fluorouracil resistance ... See more keywords
The signaling pathways implicated in impairment of hepatic autophagy in glycogen storage disease type Ia.
Sign Up to like & getrecommendations! Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaa007
Abstract: Glucose-6-phosphatase-α (G6Pase-α or G6PC) deficiency in glycogen storage disease type-Ia (GSD-Ia) leads to impaired hepatic autophagy, a recycling process important for cellular metabolism and homeostasis. Autophagy can be regulated by several energy sensing pathways, including… read more here.
Keywords: sirt1; ppar; glycogen storage; g6pc ... See more keywords