Double deficiency of isocitrate dehydrogenase-1 and glucose 6-phosphate dehydrogenase hinders growth and development in C. elegans due to altered metabolism and redox homeostasis
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DOI: 10.1016/j.freeradbiomed.2018.04.173
Abstract: Growth and development are affected by cellular redox homeostasis which is modulated partly by NADPH status. Both glucose 6-phosphate dehydrogenase (G6PD) and isocitrate dehydrogenase1 (IDH1) are responsible for the regeneration of NADPH in cells. To… read more here.
Keywords: dehydrogenase; redox homeostasis; deficient; g6pd idh1 ... See more keywords
Growth defects and metabolic alterations in IDH-1 and G6PD double-deficient Caenorhabditis elegans due to severe imbalance of redox homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.204
Abstract: NADPH plays an indispensable role in normal cellular physiology by maintaining redox homeostasis and providing reducing power for reductive biosynthesis. Isocitrate dehydrogenase-1 (IDH1) and glucose 6-phosphate dehydrogenase (G6PD) are the two major NADPH-generating enzymes in… read more here.
Keywords: redox homeostasis; g6pd idh1; double deficient; deficient ... See more keywords