Local structural unfolding at the edge-strands of beta sheets is the molecular basis for instability and aggregation of G85R and G93A mutants of superoxide dismutase 1
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DOI: 10.1080/07391102.2019.1584125
Abstract: Abstract Dynamic nature of structural segments is a key modulator of protein’s intrinsic stability. Mutants of superoxide dismutase 1 (SOD1) protein, like SOD1G85R and SOD1G93A, adopt misfolded states that undergo aggregation in motor neuron cells.… read more here.
Keywords: edge strands; aggregation; g85r g93a; beta sheets ... See more keywords